As you climb, air pressure drops. At sea level pressure is around 1013 hPa, but by 18,000 feet it has halved to about 500 hPa. The percentage of oxygen in the air stays constant at 21 percent all the way up — what changes is the partial pressure of oxygen (PPO2), and it is PPO2 that drives oxygen across the lungs into your blood. Less pressure means fewer oxygen molecules being pushed into your bloodstream per breath, even though the percentage never changes.
Hypoxia means a lack of oxygen reaching the tissues, especially the brain. It is dangerous because it degrades judgement before it causes obvious symptoms, so pilots often feel fine while actually impaired. There are four types: hypoxic (not enough oxygen available, e.g. altitude), hypemic (blood cannot carry oxygen, e.g. carbon monoxide poisoning or anaemia), stagnant (poor circulation, e.g. cold or high +G), and histotoxic (cells cannot use oxygen properly, e.g. alcohol or drug effects).
TUC is the time you have to recognise a problem and act before you are too impaired to help yourself. It shortens dramatically with altitude: roughly 20-30 minutes at 25,000 ft, 5-10 minutes at 30,000 ft, and only 30-60 seconds at 40,000 ft. Rapid decompression roughly halves these figures compared with gradual decompression at the same altitude.
Early signs include a false sense of wellbeing (euphoria), poor judgement, blue lips and fingernails (cyanosis), slowed reaction times, tunnel vision and headache. Because judgement is affected first, the pilot may not notice anything is wrong — this is the key exam trap. Night vision degrades even at fairly modest cabin altitudes, from around 5,000 ft, well before other symptoms appear.
UK/EASA rules (broadly): crew must use supplemental oxygen above 10,000 ft cabin altitude for flights over 30 minutes, and continuously above 13,000 ft cabin altitude, regardless of duration. Passengers require oxygen above 15,000 ft. These figures refer to cabin altitude, not the aircraft's true altitude, which matters for unpressurised light aircraft where cabin altitude equals actual altitude.
The eye has two receptor types. Cones give sharp colour vision in good light but need central focus - your central vision covers only about 2 degrees of your visual field in sharp detail. Rods work in dim light, give no colour, and are found outside the central fovea - which is why faint stars or lights are easier to spot slightly off to one side than by staring straight at them (off-centre viewing).
With nothing to focus on - a hazy sky, featureless cloud - the eye relaxes to a resting focus of around 1-2 metres. This means a real aircraft on a collision course can be missed until very late. The fix is deliberate, systematic scanning using short eye movements and pauses, not a continuous sweep.
Because of the central-vision limits, an effective scan uses a series of short segments (roughly 10 degrees) with a brief pause (1-2 seconds) to let the eye actually resolve detail, moving across the whole field of view. A target on a constant relative bearing with no apparent movement is the most dangerous - it is on a collision course and may stay in a blind spot (masked by the windscreen pillar) the whole time.
Rods take up to 30 minutes to fully dark-adapt, and this adaptation is destroyed instantly by bright white light. Use red cockpit lighting and avoid looking at bright screens before/during night flight. Vitamin A deficiency, smoking (raises carbon monoxide levels) and hypoxia all degrade night vision significantly - hypoxia is a bigger threat at night because rods need more oxygen than cones.
Hearing loss from repeated noise exposure is cumulative and permanent - always wear a headset. Hyperventilation and hypoxia can both affect hearing and communication before other symptoms are obvious.
The inner ear's vestibular system senses angular acceleration (semicircular canals) and linear acceleration/gravity (otoliths), but it cannot reliably tell the difference between genuine tilt and sustained acceleration - this is the root cause of illusions in IMC or at night with no visual horizon.
The rule in all cases: trust the instruments, not the sensations.
Standing still on the ground you experience 1G. In a level, unaccelerated turn or pull-up, the load factor rises above 1G because lift has to support both weight and the turning force.
Motion sickness happens when the brain receives conflicting signals from the eyes, the vestibular system (inner ear) and other body sense receptors - for example the eyes see a stable cockpit while the inner ear senses movement.
The inner ear has two jobs: hearing (cochlea) and balance (vestibular apparatus - the semicircular canals and otolith organs).
As a pilot you're legally responsible for deciding you're fit before every flight - this is the IMSAFE self-check (Illness, Medication, Stress, Alcohol, Fatigue, Eating). If in doubt, don't fly.
UK CAA guidance says even a minor cold can be dangerous. Blocked sinuses and middle ears can't equalise properly during climb and especially descent, causing severe pain (barotrauma) and possible eardrum damage. The rule of thumb: if you wouldn't drive, don't fly.
Many common over-the-counter medicines carry warnings against driving or operating machinery - the same applies to flying. Antihistamines, cold and flu remedies, and painkillers containing codeine can cause drowsiness and impair judgement, reaction time and decision-making, often without you noticing the effect yourself.
The legal limit for flying in the UK is stricter than for driving.
Fatigue is one of the biggest silent killers in aviation because it degrades decision-making, reaction time, situational awareness and mood, often before you feel obviously tired.
Stress and workload sit behind a huge share of pilot decision-making errors. The CAA wants you to recognise the difference between helpful and harmful stress, know how workload changes flying performance, and apply a structured decision-making model under pressure.
Threat and Error Management (TEM) is a framework for understanding how safe flights happen despite threats and errors being ever-present. It recognises that pilots operate in a system full of hazards and that human error is normal, not exceptional. The goal is not to achieve zero errors, but to detect and trap threats and errors before they lead to an undesired aircraft state.
Good TEM works in layers of defence. Threats should be avoided or trapped before they cause an error; errors should be trapped before they cause an undesired aircraft state; and an undesired aircraft state should be recognised and recovered from before it becomes an accident. Effective countermeasures include thorough pre-flight planning, sterile cockpit discipline during critical phases, standard callouts, checklist discipline, and maintaining situational awareness through continuous cross-checking.